1
Q
what are the 3 most common cancers associated with HPV infection?
A
anal
cervical
oropharyngeal
2
Q
what does the development of cancer caused by HPV need?
A
persistent infection
production of proteins that interfere w/ tumor suppressor genes
3
Q
what defenses are induced with HPV infection
A
innate host defenses (macrophages, inflammatory cytokines)
cell mediated immunity (CD 8 and CD 4)
antibodies (B cells, IgG, IgA)
4
Q
are vaccines for HPV made with live virus or DNA?
A
No! proteins from outer membrane
5
Q
what do the vaccines try to do?
A
induce antibodies without the activation of T cells
6
Q
what does gardasil cover?
A
16 and 18
7
Q
what does cervarix cover?
A
6,11, 18, 16
8
Q
what does gardasil 9 cover?
A
main ones + 31, 33, 45, 52, 58
