These vessels in the paracortex of lymph nodes allow T and B cells to enter the node from the blood
High endothelial venules
This part of the lymph node enlarges in an extreme immune response
Paracortex
Lymph from the lateral dorsum of the foot drains first to the _____
Popliteal nodes
Drains the right arm and right half of the head
Right lymphatic duct
Drains everything except the right arm and right side of the head
Thoracic duct
Macrophages in the spleen remove ______________ bacteria
Encapsulated bacteria
- Salmonella
- S. pneumonia
- H. Flu
- N. meningitidis
MHC 1 is found on which cells?
All nucleated cells
- not on RBCs
- MHC that mediates viral immunity
- pairs with beta 2 microglobulin
- binds CD8
MHC 1
- MHC that is expressed only on antigen presenting cells
- mediates bacterial infections
- antigens loaded following release of invariant chain in the endosome
- binds CD4
MHC II
Diseases associated with HLA B27
“PAIR”
Psoriasis
Ankylosing Spondylitis
Inflammatory bowel dz
Reiter’s syndrome
HLA associated with Hemochromatosis
HLA A3
HLA associated with Graves’ disease
HLA B8
HLA associated with MS, hay fever, Lupus, & Goodpastures
HLA DR2
HLA associated with DM 1
HLA DR3
HLA associated with Rheumatoid arthritis and DM 1
HLA DR4
HLA associated with pernicious anemia (B12 deficiency caused by autoimmune gastritis) & HASHIMOTOS thyroiditis
HLA DR5
- These cells are enhanced by IL-12, IFN-beta & IFN- alpha
- they use perforin & granzyme to kill virally infected and tumor cells
NK Cells
Antibodies that can fix complement
IgG & IgM
“GM makes classic cars”
- IgG and IgM start the “classic” complement pathway
IgE binds mast cells and basophils & crosslinks free antigen / allergens in type ______________ hypersensitivity rxns
Type 1 ( immediate)
What activates the alternate complement pathway
Microbial surfaces
Neutrophils are called by IL-______
IL-8 (“clean up on aisle 8”)
IL-_____ promotes class switching to IgA
IL-5
Which infections can you give antitoxin to counteract and give passive immunity ?
“To Be Healed Rapidly”
Tetanus
Botulinum
Hepatitis B
Rabies
IL-12 receptor deficiency causes
Decreased Th1 response, disseminated mycobacterial infections
