IVIG (IgG)
- indications
- CI
- SE
Indications-primary & secondary immune deficiency
- autoimmune disorders (x-linked agammaglobulinemia, hypogammaglobulinemia, SCID, Common variable)
- inflamm disorder
- effects may last 2wks-3mo
CI
-people w/ IgA deficiency (low IgA d/t body destroying it, if you give IgA to these pts their body will have an anaphylactic rxn b/c body recognizes IgA as non-self)
- SE
- fever
- chills
- malaise
- HA
- dyspnea
- urticaria (rash)
- anaphylaxis in IgA deficient ppl
- thrombosis
- hemolysis
- kidney injury
Hyperimmune globulin
- indications
- CI
- SE
Indications: short lived immunity against a specific organism such as Hep B, Rabies, Tetanus, Varicella Zoster
*gives immediate passive immunity
CI:
-not administered to those w/ IgA deficiencies
SE:
-decreased efficacy of live vaccines
Hepatitis B Immune Globulin
- Indications
- CI
- SE
Indications:
-past exposure, prophylaxis to Hep B
CI
-allergy to Human Immune Globulin
SE -allergic rxn =back pain -discomfort -HA -muscle pain -nausea -pain/bleeding at injection site
What is immunotherapy?
treatment that uses your body’s own immune system to help fight cancer
Rabies Immune Globulin
- indication
- CI
- SE
indication
- pts that have had rabies exposure
- never had rabies vaccine
CI
-?
SE
-?
Tetanus Immune Globulin
- Indications
- CI
- SE
indications:
- uncertain pt hx of tetanus vaccination & has unclean wound
CI
- allergy to tetanus
- IM injection d/t bleeding concerns
SE
- anaphylaxis
- angioedema
- pain or tenderness at injection site
- nephritic syndrome
Varicella-Zoster Immune Globlin
- Indications
- CI
- SE
Indications
- post exposure prophylaxis for immunocompromised ppl w/o history of immunity
- newborns of mothers w/ varicella or zoster
CI
-?
SE
- anaphylaxis
- pain at injection site
- chills
- fatigue
- rash
- Nausea
- thrombosis
What is Xolair/Omalizumab?
Anti-IgE therapy used for asthma
monoclonal Aby
this medication is used to occupy most/more of the circulating/free IgE antibodies so they do not bind to the cells»>decreasing the allergic response.
