Immunodeficiency

Question 1

What are the primary lymphoid tissues?

Answer 1

Bone Marrow

Thymus

Question 2

What are the secondary lymphoid tissues?

Answer 2

Spleen
Lymph Nodes
Tonsils
Payer’s Patches

Question 3

What are the main consequences of immuno-deficiency?

Answer 3

Infection

Cancer

Question 4

What are the main consequences of hyperimmunity?

Answer 4

Auto-immune

Allergy

Question 5

What are the primary immunodeficiencies?

Answer 5

Inherited

Congenital

Question 6

What are secondary immunodeficiencies?

Answer 6

Acquired

Question 7

Give an example of a secondary immunodeficiency

Answer 7

HIV
Steroid use
Splenectomy
Leukaemia/Lymphoma
Malnutrition

Question 8

Give an example of a primary immunodeficiency

Answer 8

Severe Combined Immunodeficiency (inherited stem cell defect)
DiGeorge Syndrome (defect of development of pharyngeal arches)

Question 9

What are the antibody isotypes?

Answer 9

IgM (Pentamers)
IgG (Monomers)
IgA
IgE (Monomers)