Immunology

Question 1

What is the definition of anaphylaxis

Answer 1

Acute onset Skin signs (urticaria, flushing, oedema)
AND EITHER
- Resp: bronchospam/stridor/hypoxia
- Cardio: Hypotension with end organ dysfunction (collapse/syncope)
- Severe GI (Abdo pain/vomiting) WITHOUT food born allergen

OR

Acute (minutes to hours) hypotension or bronchospasm or upper airway obstruction after exposure to known or highly probably allergen

Question 2

Who needs prolonged/overnight monitoring post treatment of anaphylaxis

Answer 2

Required multiple doses of adrenalin
History of severe or protracted anaphylaxis
Concomitant illness (severe asthma, arrhythmia, systemic mastocystosis)
Lives alone or remote
Presenting late in the evening