Which cytokines stimulate secretion of acute phase proteins like fibrinogen?
Il-1
IL-6
TNF-alpha
Bradykinin
vasodilation
Increased permeability of vessels
mediates pain
smooth muscle contraction!
Leukotriene B4
neutrophil migration
Platelet activating factor
vasoconstriction
platelet stimulation
Leukocyte adhesion
thromboxane A2
platelet aggregation and vasoconstriction
IL-12
stimulates natural killer cells and Thelper cells to secrete IFN-y
Interferon-alpha
antiviral/antitumor activity
IL-3
Stimulates immature T cells in bone marrow to mature
Which cytokines are responsible for SIRS?
TNF-a
IL-1
IL-6