Immunology

Question 1

Type I hypersensitivity

Answer 1

IgE mediated, immediate

Question 2

Type II hypersensitivity - what it is, examples

Answer 2

Direct cell killing: antibody mediated
Activation of complement + opsonisation
Eg: Autoimmune haemolytic anaemia, ABO transfusion reaction, thrombocytopaenic purpura

Question 3

Type III hypersensitivity, example

Answer 3

Immune complex mediated, eg SLE

Question 4

Type IV hypersensitivity, examples

Answer 4

Delayed type (days)
cell-mediated (T cells: CD4 helper and CD8 cytotoxic cells)
Eg: T1 diabetes, IBD, MS, rheumatoid arthritis