Path Past > Immunology > Flashcards

Immunology Flashcards

(84 cards)

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1
Q

How to monitor SLE

A

C3 and C4

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2
Q

HIV Test

A

Western Blot

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3
Q

Anti-SCL70

A

Systemic Sclerosis (TGF B linked to prognosis somehow)

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4
Q

Anti-Sm

A

SLE

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5
Q

HIV Monitoring

A

CD4 levels and viral load

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6
Q

Anti-cardiolipin

A

Antiphospholipied Syndrome

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7
Q

Nose bleeds and haematuria

A

Wegener’s Granulomatosis c-ANCA

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8
Q

Pruritus in a woman (PBC) What antibody

A

Anti-mitochondrial antibody

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9
Q

Wegeners patient already getting prednisolone and needs another drug

A

Cyclophosphamide

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10
Q

Rheumatoid arthritis DMARD

A

Tocilizumab

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11
Q

Psoriasis or Psoriatc Arthritis DMARD

A

Ustekinumab

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12
Q

Temporal Arteritis (Raised ESR) drug

A

Prednisolone

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13
Q

Osteoporosis DMARD

A

Denosumab

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14
Q

CGD Management

A

Infliximab

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15
Q

Worsening Crohn’s patient already taking azathioprine

A

Methotrexate

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16
Q

Ankylosing Spondylitis

A

NSAID. If uncontrolled, Infliximab

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17
Q

Common variable immunodeficiency management

A

Pooled Ig

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18
Q

C1 esterase inhibitor deficiency patient can talk

A

IV C1 inhibitior

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19
Q

Rash after eating in a patient

A

oral antihistamines (h1)

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20
Q

Anaphylaxis

A

IM Adrenaline

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21
Q

Urticaria

A

H1 anatgonist

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22
Q

Exercise induced urticaria

A

H1 antagonist

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23
Q

Acute angiodema

A

IM Adrenaline

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24
Q

Hayfever management

A

Allergy desensitisation

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25
Cytokine responsible for promoting antibody synthesis
IL4
26
Main cellular source of histamine
Mast Cell
27
How to measure mast cell degranulation
Serum tryptase levels
28
Chemokine responsible for eosinophil growth
IL5
29
First cell for initial encounter with allergen
Macrophage
30
IL4 stimulates
B cells
31
First cytokine released in contact dermatitis
IL-12
32
Carcinoid syndrome?
Enterochromaffin cell tumour producing serotonin. Causing bronchoconstriction, flushing, diarrhoea. Give Octreotide
33
MEFV gene is mutated in...
Familial Mediterranean Fever
34
gp120 binds to
CCR5 or CXCR4
35
gp41
Allows penetration
36
Non neutralising antibodies are formed against
p24
37
Protease inhibitor
Ritonavir
38
Neutralising antibodies
anti-gp120 anti-gp41
39
CCR7
chemokine receptor on t helper cells
40
Target for HIV medication
Protease inhibitor
41
A 6-month old boy with severe failure to thrive and recurrent infections etc… his T cells were undetectable and B cells were normal.
SCID
42
Someone with three previous episodes of meningococcal meningitis
C7 deficiency
43
Someone with normal CD8 levels but absent CD4
Bare lymphocyte Syndrome
44
Low IgA, IgG but raised IgM
CD40L deficiency/Hyper IgM syndrome
45
Kid with immune def that has improved with age but now mum is concerned about delayed speaking and language
Di George Syndrome
46
Patient gets recurrent infections with negative NBT and dihdrorrhadamine tests
Chronic Granulomatous Disease
47
Atypical granulomatous infection in previously healthy patient. Recurrent salmonella and mycobacteria infections
IFN-gamma receptor deficiency or IL-12 deficiency
48
Patient treated for RA getting mycobacterial infections
Iatrogenic due to infliximab
49
Vaccine to avoid in immunodeficiency
Yellow Fever
50
Asplenic patients vaccine every 5 years
Pneumovax
51
Avoid routine vaccine in immunodeficient patient
MMR
52
Which one against viral haemagglutinin
Influenza
53
Vaccine that you shouldn't give to someone on infliximab if theyre travelling to Africa
Typhoid
54
Vaccine sometimes used post exposure as prophylaxis
Rabies
55
Vaccine which changes every year due to change in structure of pathogen
Influenza
56
Name of vaccine that eradicated smallpox
Vaccinia
57
What vaccine don't you give to someone with Ank Spond on Infliximab
Yellow fever
58
What vaccine do you give to 12-13yr old girls
HPV
59
Graves Disease Immune Type
II
60
Serum Sickness Immune Type
III
61
Atopic Eczema
I
62
CD40L is associated with
Hyper IgM syndrome
63
Anti-Ro Anti-La
Sjogrens
64
Anti-ttg
Coeliac
65
CREST
anti-centromere
66
SLE
anti-dsDNA
67
Pernicious anaemia
Anti-parietal cell
68
What is most important in HLA typing?
DR>B>A
69
Antibodies against endothelial cells in transplant rejection
Acute vascular
70
T-cells mediating rejection
Acute cellular
71
Super fast rejection straight after insertion
HLA Typing or ABO mismatch
72
Rejection years after
Immune and non immune
73
Donor cells attack host resulting in hyperacute rejection
GVHD
74
Immune Modulator Anti-CD25
Basiliximab
75
Immune Modulator IL6 R
Tocilizumab
76
Immune Modulator IL12/23
Ustekinumab
77
Immune Modulator CTLA4
Abatacept
78
Immune Modulator CD2
Alemtuzumab
79
Immune Modulator TNF alpha
Infliximab
80
Immune Modulator Anti C5
Ecalizumab
81
Immune Modulator VCAM 1
Natalizumab
82
APECED mutation
AIRE
83
IPEX mutation
FOXP3
84
APLS mutation
Fas
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