immunosuppression

Question 1

three main immunosuppression indications

Answer 1

• autoimmune diseases
• hypersensitivity diseases
• transplantation

Question 2

immunosuppression drug groups

Answer 2

• antimetabolites
• alkylating agents
• glucocorticoids
• cytokine gene expression inhibitors

Question 3

antimetabolites types

Answer 3

• purine analogues
• pyrimidine analogues
• folic acid antagonists

Question 4

alkylating agents

Answer 4

cyclophosphamide

Question 5

cytokine gene expression inhibitors

Answer 5

calcineurin-inhibitors

Question 6

list of antimetabolites

Answer 6

• azathioprine
• mycophenolate mofetil
• methotrexate

Question 7

release azathioprine

Answer 7

slow release -> longer effect

Question 8

azathioprine admin route

Answer 8

Iv or oral

Question 9

mycophenolate mofetil is it a prodrug

Answer 9

yes

Question 10

mycophenolate specificity

Answer 10

expecially specific to T and B lymphocytes

Question 11

mycophenolate safety

Answer 11

much safer than azathioprine

Question 12

whats methotrexate

Answer 12

a folic acid antagonist

Question 13

which cells are affected most by cyclophosphamide

Answer 13

B and T cells equally effected

Question 14

whats cyclophosphamide

Answer 14

its an alkylating agent

Question 15

name two calcineurin inhibitors

Answer 15

cyclosporin and tacrolimus

Question 16

calcineurin inhibitors mechanism of action

Answer 16

• inhibition of calcineurin
• mastocyte inhibition, inhibition of degranulation
• decr IL and TNF-alpha expression

Question 17

cyclosporin application

Answer 17

per os and locally

Question 18

cyclosporin indications

Answer 18

• autoimmune diseases
• atopic dermatitis
• IBD

Question 19

cyclosporin side effects

Answer 19

• GI vomiting, diarrhoea
• alopecia
• gingival hyperplasia