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Important cytokines Flashcards

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1
Q

IL-1

A
  • AKA osteoclast activating factor
  • Causes fever, acute inflammation
  • Activates endothelium to express adhesion molecules
  • Induces chemokine secretion to recruit WBCs
  • Secreted by macrophages
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2
Q

IL-6

A
  • Causes fever and stimulates produce of acute phase proteins
  • Secreted by macrophages
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3
Q

IL-8

A
  • Major chemotactic for neutrophils

- Secreted by macrophages

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4
Q

IL-12

A
  • Induces differentiation of T cells into Th1 cells
  • Activates NK cells
  • Secreted by macrophages
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5
Q

TNF-alpha

A
  • Mediates septic shock
  • Activates endothelium
  • Causes WBC recruitment, vascular leak
  • Causes cachexia in malignancy
  • Secreted by macrophages
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6
Q

IL-2

A
  • Stimulates growth of helper, cytotoxic and regulatory T cells
  • Stimulates growth of NK cells
  • Secreted by all T cells
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7
Q

IL-3

A
  • Supports growth and differentiation of bone marrow stem cells
  • Functions like GM-CSF
  • Secreted by all T cells
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8
Q

Interferon-gamma

A
  • Secreted by NK cells and T cells in response to IL-12 from macrophages
  • Stimulates macrophages to kill phagocytosed pathogens
  • Inhibits differentiation of Th2 cells
  • Activates NK cells to kill virus infected cells
  • Increases MHC expression and antigen presentation by all cells
  • Secreted by Th1 cells
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9
Q

IL-4

A
  • Induces differentiation of T cells into Th2 cells
  • Promotes growth of B cells
  • Enhances class switching to IgE and IgG
  • Secreted by Th2 cells
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10
Q

IL-5

A
  • Promotes growth and differentiation of B cells
  • Enhances class switching to IgA
  • Stimulates growth and differentiation of eosinophils
  • Secreted by Th2 cells
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11
Q

IL-10

A
  • Attenuates inflammatory response
  • Decreases expression of MHC class II and Th1 cytokines
  • Inhibits activated macrophages and dendritic cells
  • Also secreted by regulatory T cells
  • TGF-beta and IL-10 both atTENuate the immune response
  • Secreted by Th2 cells
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12
Q

Secreted by macrophages

A
  • IL-1
  • IL-6
  • IL-8
  • IL-12
  • TNF-alpha
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13
Q

Secreted by all T cells

A
  • IL-2

- IL-3

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14
Q

Secreted by Th1 cells

A
  • Interferon-gamma
  • IL-2
  • IL-3
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15
Q

Secreted by Th2 cells

A
  • IL-4
  • IL-5
  • IL-10
  • IL-2
  • IL-3
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