GIRLS with ADHD tend to have what predominant symptoms?
INATTENTIVENESS
what percent of children with ADHD go onto adult ADHD?
60%
What is the gender difference in prevalence of Tourettes?
M>F
What do PET studies suggest about the pathophysiology of Tourettes?
Increased DA activity in Ventral Striatum
AND
Abnormal release and uptake of DA.
Dopaminergic neurons in what part of the brain is linked with Tourettes and development of motor tics?
How?
DA neurons in Caudate Nucleus
Caudate D2 receptor overstimulation causes tics and movements
What is the most common congenital viral infection in new borns?
CMV
Most infants with inutero CMV infections…what symptoms can they have?
- Microcephaly
- Hepatosplenomegaly
- Jaundice
- Chorioretinitis
- Ataxia
- Seizures
What ADHD medication would you consider when treating ADHD in a person with comorbid TIC disorder?
What is the MOA of this drug?
Atomoxatine (Stratera) = Selective NE reuptake inhinitor (not a stimulant)
(Stimulant ADHD medication will worsen TICS)
What is the diagnostic criteria for intermittent explosive disorder?
- Recurrent behavioral outbursts (either verbal or physical to person/property) due to failure to control aggressive impulses.
- Aggression grossly out of proportion to trigger
- Outburst NOT premeditated and unpredictable.
- Only diagnosed after 6 year of age or older.
Intermittent explosive disorder is highly comorbid with what 3 illnesses or behaviors?
What is the mainstay of treatments?
- Fire setting
- Eating disorders
- Substance use
Treatments: Mood stabilizers (Lithium, VPA, Carbamazepine, Gabapentin) and SSRI/TCAs.
