- two or more failed clinical pregnancies as documented per ultrasound or histopatholigical exam - three consecutive pregnancy losses (do not have to be IUPs)

- acquired and congenital abnormalities are responsible for 10-50% of RPL - can depend on population - requires further examination/investigation

Infertility Flashcards by Alisha Stubbs

RPL

two or more failed clinical pregnancies as documented per ultrasound or histopatholigical exam
three consecutive pregnancy losses (do not have to be IUPs)

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uterine factors

acquired and congenital abnormalities are responsible for 10-50% of RPL
can depend on population
requires further examination/investigation

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endocrine causes of RPL

diabetes
thyroid abnormalities
luteal phase defects and low progesterone
PCOS

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immunological causes of RPL

antiphospholipid antibody syndrome

- blood group alloimmunization

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genetic causes of RPL

aneuploidy
chromosomal rearrangements
inherited thrombophilias

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chromosomal difference incidence in RPL couples

-4% have this (versus 0.7% of the general population)
+40% with Robs
+60% with reciprocal

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environmental causes of RPL

chemical agents (benzene, formaldehyde)
smoking
illicit substance use
infection

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Infertility Flashcards

(7 cards)