S.N Pathology I > Inflamation > Flashcards

Inflamation Flashcards

(44 cards)

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1
Q

What are the main cellular components in acute inflamation?

A

Neutrophils

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2
Q

What are the main cellular components in chronic inflamation?

A

Monocyes/MPH and Lymphocytes

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3
Q

Examples for vasoactive materials in acute inflamation

A

Histamine
Serotonine
Bradyknin
Leukotrians

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4
Q

Examples for chemotactic madiators in acute inflamation

A

Complement proteins (5ca)
Lymphotoxins Beta
Peptides

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5
Q

What is the immidiate response for cell injury?

A

Vasoconstriction

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6
Q

For how long does vasoconst. lasts?

A

Few seconds

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7
Q

What is the name for protein rich fluid in inflamation?

A

Exudate

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8
Q

Describe what is Transudate

A

Interstitial fluid accumulation caused by increased Hydrostatic P

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9
Q

Describe Leukocytes activation

A
  1. Chemoattraction
  2. Rolling-Adhesion
  3. Tight binding
  4. Transmigration
  5. Chemotaxins
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10
Q

Main events durring Chemoattraction

A

MPH release cytokines

Endot. cells express adhesion molecules

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11
Q

MPH release cytokines.

Which are they?

A

IL-1
TNF-a
Chemokines

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12
Q

Endot. cells express adhesion molecules.

Which arre they?

A

Selectins

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13
Q

Main events durring Rolling-Adhesion

A

Carbohydrate ligands on circulating Leukocytes binds to Selectin molecules

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14
Q

Main events durring Tight binding

A

Binding is mediated by ICAM proteins

Surface Integrins on Leukocytes become high-affinity

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15
Q

Main events durring Transmigration

A

Leukocytes cross the Endot. wall

Penetrate bsement memb. with help of hydrolytic enzymes

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16
Q

How do we call the movement od Leukocytes through the basement memb.?

A

Dipedesis

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17
Q

Main events durring Chemotaxins

A

Leukocytes move towards site of injury

Mediated by Chemokines and Chemoattractant

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18
Q

Types of acute inflammation

Study These Flashcards
A 
Serous
Fibrinous
Purulent
Hemorrhagic
Gangrenous
19
Q

Describe Serous inflammation

Study These Flashcards
A
  • Exudate is watery and protein poor

- Fluid may derive from plasma orsecretion of mesothelial cells (lining pleura/pericardium)

20
Q

Examples for Serous inflammation

Study These Flashcards
A

Endocarditis serosa

Meningitis serosa

21
Q

Describe Fibrinous inflammation

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A
  • Consequence of more severe injury
  • Pseudomembranous inflammation
  • Fibrinous exudate may be dissolved by Fibrinolysis
  • Can lead to scarring if not removed
22
Q

Examples for Fibrinous inflammation

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A 
Fibrinous Pericrditis
Fibrinous Pleuritis
Fibrinous Peritonitis
Lobar Pneumonia
Pseudomembranous Colitis
23
Q

Describe Purulent inflammation

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A
  • Large amounts of Purulent Exudate ( Pus= Neut, Necrotic cells, Edema fluids)
  • Abscesses (Focal cillections of Pus)
24
Q

Examples for Purulent inflammation

Study These Flashcards
A

Purulent Pleuritis
Purulent Meningitis
Purulent Broncho-Pneumonia

25
Describe Hemorrhagic inflammation
- Damage to capillary Endot. integrity -> Bleeding | - Exudate usually contains blood
26
Examples for Hemorrhagic inflammation
Hemorrhagic Tracheitis Hemorrhagic Pneumonia Hemorrhagic Enteritis Anthrax
27
Describe Gangrenous inflammation
- Collection of activated MPH often with T cells - Sometimes associated with necrosis - Usually form of chronic infl.
28
Examples for Gangrenous inflammation
Gangrenous Pneumonia
29
Describe Empyema
Collection of Pus inside naturally existing cavity
30
Possible outcomes of acute infl.
Scar formation Regeneration and repair Persistant infection or failure of healing -> chronic infl.
31
Describe what is Subacute inflammation
Transition btw acute and chronic inflammation
32
Another name to redness
Rubor
33
Another name to warm
Calor
34
Another name to Painful
Dolor
35
Localized form of acute purulent inflammation forming a pus filled cavitiy
Abscess
36
Pus in preformed cavity
Empyema
37
Diffused form of acute purulent inflammation, spreading within a tissue
Phlegmon
38
What is Granuloma
Small roundish aggregation of epitheloid MPH and giant cells
39
Types of multinucleated giant cells?
Foreign body Langerhans Touton
40
Example for Rheumatic granuloma
Aschoffs nodule
41
Describe primary wound healing
Sterile Cut wounds Sharp edges
42
Describe secondary wound healing
Damaged wounds Loss of tissue Infected wounds
43
Phases of wound healing
Exudative Resorptive Proliferative Reparative
44
Proliferative phase of wound healing happens in day __
3
S.N Pathology I
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