Inflammation

Question 1

H1 histamine receptor

Answer 1

Couples via Gq/11 -> PLCβ -> [Ca]i
Important in inflammation
Targeted by ‘antihistamines’

Question 2

H2 histamine receptor

Answer 2

Couples via Gs -> AC -> cAMP

Important in gastric acid secretion

Question 3

H3 histamine receptor

Answer 3

Couples via Gi -> AC -> cAMP

Important in CNS- presynaptic inhibition by Ca influx

Question 4

H4 histamine receptor

Answer 4

Couples via Gq/11 -> PLCβ -> [Ca]i

Physiological role unknown.