1
Q
In terms of CYP450 metabolism, what is grapefruit?
A
3A4 and 1A2 inhibitor
2
Q
In terms of CYP450 metabolism, what is azoles e.g. flucaonazole?
A
3A4 2C19 2C9 1A2 inhibitors
3
Q
In terms of CYP450 metabolism, what is macrolide?
A
3A4 and 1A2 inhibitor
4
Q
In terms of CYP450 metabolism, what is rifamipicin?
A
2C19, 2C9, 3A4, 2C8 and 1A2 inducer
5
Q
In terms of CYP450 metabolism, what is ethanol?
A
2E1 inducer
6
Q
What is the most common CYP450 sub type?
A
3A4
7
Q
What drugs are metabolised by 3A4?
A
CCBs
Statins
8
Q
How is warfarin and NSAIDs metabolised?
A
2C9
9
Q
In terms of CYP450 metabolism, what is St John’s Wort?
A
3A4 inducer
10
Q
What are the most powerful enzyme inducers?
A
Rifampicin
Antiepileptics- phenytoin and carbamazepine
Smoking, alcohol (chronic use), St John’s wort
CDM
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