Intercalating agents

Question 1

Is Doxorubicin and specific or non specific DNA intercalating agent?

Answer 1

Non-specific

Question 2

Doxorubicin induces protein ______ ____ ____.

How does it do this?

Answer 2

Associated strand breaks

It traps topoisomerase II that is covalently bound to DNA

Question 3

Define intercalation…

Answer 3

Insertion of a flat aromatic molecule between adjacent base pairs of the double helix

Question 4

Selectivity of agents that target cellular processes might be dependent on the level of the associated target protein e.g. topoisomerase I or II so cells with elevated levels of topoisomerase would be _____ susceptible to doxorubicin - enhanced cancer cell selectivity

Answer 4

MORE