Intercalators

Question 1

Intercalator general MOA

Answer 1

“slip” in between stacked bases of DNA and disrupt its normal operation - ie - DNA and RNA synthesis.
cause radical formation and break DNA strand. Inhibit Topo2. Stack and stretch DNA mismatch.

Question 2

Anthracycline agent example

Answer 2

Doxorubicin

Question 3

Doxorubicin

Answer 3

blood red color. Toxicity caused by =O and –OH chelation. Myocardial tox Heart failure
—Cells have ion pool which is where cardiotoxicity
Give Dexrazoxane

Question 4

Dexrazoxane

Answer 4

Give before doxorubicin to reduce heart failure. Complexes with iron. But enhances myelosuppression caused by doxorubicin.