IL-1
Stimulates IL-6 and increases vascular endothelium permeability
IL-6
Liver: Production of acute phase proteins and fever (inflammation)
IL-8
Activation of neutrophils and activation of vascular endothelium
IL-12
NK cells—activates them and promotes lymphocyte differentiation
TNF-⍺
Increased permeability and activation of vascular endothelium
IL-12
Influences Th0 cells to differentiate into Th1 cells
IL-4 & IL-10
Influences Th0 cells to differentiate to Th2 cells which stimulate B cells to differentiate into plasma and memory cells
IL-6, IL-21, TGF-β
Promote generation of Th17 which promotes the recruitment of neutrophils and inflammation and anti-microbial immune responses.