Interstitial Nephritis

Question 1

what is this?

Answer 1

inflammation of the kidney interstitium

• acute
• chronic

Question 2

how does acute interstitial nephritis present?

Answer 2

AKI and hypertension

Question 3

what is acute interstitial nephritis caused by?

Answer 3

typically caused by hypersensitivity reaction to:

drugs (NSAIDs or Abx)

infection

other features of hypersensitivity may be present ie rash, fever

Question 4

how does chronic interstitial nephritis present?

Answer 4

with CKD

Question 5

Mx of both?

Answer 5

• treat underlying cause
• steroids may play a role in reducing inflammation