1
Q
What is a drug
A
A compound which interacts with a biological system to produce a biological response
2
Q
The therapeutic index
A
Shows the ratios of concentrations at which a drug is effective versus toxic
3
Q
ADMET
A
Absorption Distribution Metabolism Elimination Toxicity
4
Q
Types of molecular target
A
Proteins (Enzymes, Receptors, and Ion channels) Lipids Nucleic acids Carbohydrates
5
Q
Druggability
A
A target that is capable of binding a small molecule capable of modulating its activity in a therapeutically desirable way
6
Q
Protein-protein interactions (PPIs)
A
Modulate a lot of biochemical processes. Large molecules so spread over large surface area. Involves 2 fairly flat surfaces without defined pockets or grooves.
7
Q
Intermolecular interactions
A
Salt bridges (strongest)
Hydrogen bonding
Van deer waals (weakest)
Drug Design
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