How much does FeLV infection increase the risk of developing lymphoma?
62-fold
Which percentage of cats with FeLV develops haematopoetic neoplasms?
23%
How does FeLV-infection increase the risk of developing lymphoma?
A viral domain is integrated in relation to a proto-oncogene
Name 6 proto-onco genes associated with tumour genesis in FeLV-infection?
MYC, FLVI-1, FLVI-2, FIT-1, PIM-1 and FLIT-1
Which region of the retrovirus promote transcription and cell proliferation?
U3
Is survival influenced by FeLV-status?
Yes, they have similar remission rates but shorter survival times.
Which protocol has been suggested used for multi centric and mediastinal LSA in cat?
LOPH
Define the clinical staging system for feline lymphoma by Terry et al:
- Single tumour ( extra nodal or nodal, including mediastinal.)
- Single tumour with regional lymph node involvement, two or more nodal areas on the same side of the diaphragm, two single tumours with or without regional lymph node involvement on the same side of the diaphragm. resectable primary GI tumour - with or without mesenteric nodes associated.
- two single tumours opposite sides diaphragm, all extensive primary unresectable intraabdominal disease, all paraspinal or epidural tumours, regardless of tumours site or sites.
- 1-3 and liver or spleen involvement
- 1-4 with initial involvement of CNS or bone marrow.
Which types of LSA is mostly associated with FeLV infection?
Mediastinal and multi-centric lymphoma
Is there difference in prognosis between mediastinal lymphoma in young FeLV positive cats vs. not?
Yes, for positive cats the prognosis with mediastinal LSA is very poor with 2-3 months survival expected after treatment. Siamese predisposed for LSA, survival better with MST 400 d, up to 980 d if CR achieved.
By which mechanism is doxorubicin nephrotoxic in cats=
It is related to release of reactive oxygen species
