What is the first law of thermodynamics?
Energy cannot be created or destroyed, it can just be tranferred from one form of energy to another. (chemical, mechanical, electrical or heat)
What is the second law of thermodynamics?
All energy used by the body degenerates as heat
What is a calorie?
The amount of heat required to raise the temperature f 1g of water by 1’C
How many calories in each macronutrient?
1g carbs: 4kcal, protein: 4, Fat; 9, Alcohol: 7, Fibre: 2.
What are the key nutrients for energy production?
Mg, Manganese, Fe, Sulphur, COQ10, Copper, Vit B1, b2, B3, B5, Alpha-lipoid acid
What substances can interfere with energy production?
Heavy metals - mercury, arsenic etc. Toxins
What are the three variables of total energy expenditure?
Basal metabolic rate (60-75%), physical activity and the thermic effect of food
What factors can raise basal metabolic rate?
stress, caffeine, nicotine, exercise, meds, fever, injury, genetics, hyperthyroidism
What are the two thyroid hormones?
Thyroxine (T4), Triiodothyronine (T3)
Which nutrients are needed for thyroid hormone production?
Iodine, tyrosine, zinc, selenium and iron
What is subclinical hypothyroidism?
Raised TSH but normal T4 and T3
Can have some hypothyroid symptoms
Which food groups have the largest thermic effect?
Proteins (20-30%)
Carbs (5-10%)
Fats (0-3%)
How much energy does it take to store carbs as fat?
30% - except fructose which converts easily
What macronutrient ratios are best for gaining muscle and losing weight?
gaining muscle: high carb and high protein
losing weight: high protein lower carbs
What is the process of ketosis?
When glucose is insufficient, the brain sees it as a stressor and cortisol increases this causes a drop in insulin causing an excess supply of fatty acids from adopose tissue which are turned into ketones
What causes a feeling of satiety?
GI distension activates mechanoreceptors, CCK is released, liver detects nutrients - sent back to brain by the vagus nerve
Which part of the brain controls appetite?
The arcuate nucleus of the hypothalamus
Which neurotransmitters/hormones increase appetite?
neuropeptide Y, Insulin, Ghrelin
Which neurotransmitters/hormones decrease appetite?
CCK, Glucagon, GLP-1, Bombesin, Leptin
What causes CCK to be released?
The presence of food in the duodenum, especially with high fat and protein
What are the actions of CCK?
Stimulates the gallbladder to release bile, and pancreas to release enzymes, delays gastric emptying, stimulates satiety centres
What are the actions of insulin?
what is adiponectin?
An adipose-specific protein hormone that increases the oxidation of fatty acids, promotes the clearance of excess fat in tissues and improves insulin sensitivity
What does visceral fat release?
Inflammatory cytokines - TNF-a and IL6 which further promotes insulin resistance and obesity