Synthesis of ketone bodies which serve as alternative for peripheral tissues
KETOGENESIS
Site of ketogenesis
LIVER
MITOCHONDRIA
Substrate for Ketogenesis
Acetyl CoA
Products of Ketogenesis
ACETOACETATE
B-HYDROXYBUTYRATE
ACETONE
Rate Limiting Step of Ketogenesis
Acetoacetyl CoA + Acetyl CoA –> HMG CoA
HMG COA SYNTHASE
Produced ATP when acetoacetate is the end product
26 mol of ATP
Produced ATP when B-hydroxybutyrate is the end product
21 mol of ATP
Primary Ketone Body
Acetoacetate
Secondary Ketone Bodies
Acetone
Beta Hydroxybutyrate
Neutral Ketone Body
Acetone
Ketone body excreted through lungs
Acetone
Site of synthesis of ketone bodies
Liver Mitochondria