L286 Why Exercise?

Question 1

Exercise capacity and mortality: evidence for relationship

Answer 1

• ↓ MET → ↑ risk of death, ↑ MET → ↑ years of life gained, ↓ mortality

Question 2

Physical activity and obesity: relationship

Answer 2

• ↓ physical activity, ↑ obesity

Question 3

Role of sitting in ill-health

Answer 3

• ↑ sitting (even if active), ↑ risk of death

Question 4

Comment on the possible role of an ‘exercise pill’ as therapy

Answer 4

• AMPK and PPARδ agonists are exercise mimetics - but does it work?
  
  • They may be mimetics, but its not possible to re-capitulate all factors of exercise
• However, might this be useful as adjunct therapy (e.g. in people who cannot exercise)