Evolution of Viruses: 3 hypthesises
Regressive hypothesis
viruses evolved from free-living cells or from intracellular prokaryotic
Self-replicating hypothesis
viruses may have originated form self-replicating entities similar to transposons or other mobile genetic elements
Progressive or Escapist hypothesis
Viruses originated from pieces of RNA and DNA that escaped from a host cell and gained ability to move between cells
Virus shapes:Filamentous
long, thin worm-like shape
Virus shapes: Isometric
spherical-shape
Virus shapes: Enveloped
have membranes that surround capsids
Virus shapes: Complex/head and tail
infect bacteria and have a head that is similar to icon a hedral viruses and a tail shaped like helical viruses
Dna viruses
double stranded; replication takes place in nucleus; few have DNA polymerase and can replicate in host cell’s cytoplasm
Rna viruses
usually single-stranded; replication takes place in cytoplasm; mutation happens at a very high rate because RNA polymerase does not proofread
Four steps of viral infection
Attachment
receptors on cell bind to virus capsid protein or envelope glycoproteins
Entry
virus enters eukaryotic cells by endocytosis or if envelope by fusions w cell membrane
Replication and assembly
depends on RNA, DNA and retrovirius and reverse transcriptase
Egress
release; may involve lysis and death of host cells, may involved budding (not kill cell)
Lytic cycle
lyse the host cell after replication
lysogenic cycle
do not immediately lyse host cell; bacterial phage genome integrates with host genome and replicates with it without destroying cell; when conditions deteriorate the virus lyses the cell
Reverse transcriptase virus
never occurs in an uninfected host cell - the enzyme reverse transcriptase is only derived from the expression of viral genes within the infected host cell
vaccines
primary method of controlling viral disease; prepared using live, killed or molecular sub units of viruses
prion
proteinaceous infectious particles; no DNA or RNA; cause fatal neurodegenerative diseases, not destroyed by cooking
Viriods
small circles of RNA Iplants)
prokaryote structure
no membrane-bound organelles; no nucleus; DNA in nucleoid; free ribsomes
Extremophiles
adapted to grow under extreme conditions (deeps sea, heat, dry, cold, radiation)
Acidophiles: extreme
low pH