For every 0.1 change in pH, K will change by _________
0.6 in OPPOSITE direction
For every 10mEq/L change in HCO3, pH will change ________
0.15 in the SAME direction
For every 10mmHg change in CO2, pH will change ________
0.08 in OPPOSITE direction
Sodium Normals
135-145
- determines osmotic pressure
- dominant extra cellular cation
Hyponatremia
<135 mEq/L
Causes: vomiting/diarrhea, volume overload, loss of water (SIADH)
Hypernatremia
> 145
Causes: sweating, diarrhea, Cushing’s syndrome, DI
Potassium Normals
3.4-5.0 mEq/L
- regulated by kidneys
- in acidosis, H shifts K out of cells causing increase in labs
Hyperkalemia
> 5 mEq/L
Symptoms: slow wide V tach (QRS), peaked T waves, tachycardia
Treatment: Ca gluconate, glucose, insulin, alb
Hypokalemia
<3.5 mEq/L
Symptoms: hypotension, vent arrhythmias, cardiac arrest
** prominent U waves, T waves flat/inverted
Treatment:
- give K
Calcium Normals
8.5-10.5
- muscular contraction, excitability, coagulation
Hypocalcemia
Cramping, tingling, AMS
Causes: diarrhea, renal failure, alkalosis
- reciprocal relationship with phosphorous
Hypercalcemia
Pain, N/V, AMS, polyuria, polydipsia
Causes: renal impairment, decreased phos
Chvostek’s Sign
Hypocalcemia/Hyperphosphatemia
- touching side of cheek causes draw up of cheek/lip
Trousseau’s Sign
Hypocalcemia/Hyperphosphatemia
- hand flexed to forearm (during BP)
Magnesium
1.5-2.5
Hypo: torsades, tremors
Hyper: AMS, decreased RR, decreased DTR, decreased BP
Chloride
95-105
- follows Na and water
- deficiency in Cl = decrease K and vice versa
Creatinine
0.6-1.2
- waste product of muscle metabolism
Increase: shock, rhabdo, dehydration
Decrease: pregnancy
BUN
6-23
- measures glomerular function
- is a urea waste product of liver
Increase: renal failure, hypovolemia, CHF, dehydration
Decrease: liver failure, malnutrition, excessive IVF
Anion Gap
Uncorrected: 9-12
K corrected: 16-20
- measurement between cation and anion
Betahydroxybutyrate (BHB)
0.4-0.5
- predominate ketone body at onset of DKA
BNP
<100
- secreted by cardiomyocytes based on vetricular stretch
Troponin
<0.4
- protein essential for muscle contraction
- calcium binding site
-increases after injury
Creatine Kinase (CK)
0-3
- enzyme in cardiac and some skeletal muscles
- normally undetected
Serum Osmolality
275-305 (double Na norm)
Increase: dehydration, DI, hyperglycemia, hypernatremia
Decrease: SIADH, hyponatremia, overhydration