What did Descartes compare memory to in 1664?
An imprint left on linen cloth after needles pass through.
Define learning.
Gaining new information.
Define memory.
Retention of learned information.
Define consolidation.
Solidification of new memory.
What is an engram?
A memory trace in the brain.
What is recall?
Retrieval of stored memory.
What is amnesia?
Memory failure.
What is retrograde amnesia?
Loss of old memories.
What is anterograde amnesia?
Inability to form new memories.
What is transient global amnesia?
Brief anterograde amnesia paired with retrograde amnesia.
Why is Henry Molaison important?
His medial temporal lobe removal cured epilepsy but caused severe anterograde amnesia.
What could HM still do despite his memory loss?
Learn new motor skills.
What was unique about HM and the star-tracing task?
He improved through practice but could not remember doing it.
What is declarative memory?
Facts, events, names; requires conscious recall; easily formed and forgotten.
What is implicit memory?
Skills, habits, emotional associations; does not require conscious recall; needs repetition.
Examples of implicit memory?
Motor skills, conditioning, habituation, sensitization.
How long does working memory last?
Seconds; maintained by rehearsal.
How long does short-term memory last?
Minutes to hours; vulnerable to disruption.
How long does long-term memory last?
Days to years; less vulnerable to disruption.
What is working memory?
Transient small-capacity memory requiring rehearsal; independent of the temporal lobe.
Which brain regions support working memory?
Prefrontal cortex (PFC) and neocortex.
How is working memory tested?
Delayed match/non-match to sample tasks.
What happens with PFC lesions?
Impaired planning, maze-tracing, and event organization.
What neurons encode working memory?
PFC neurons that fire persistently during the delay period.