Lects. 7-10 Flashcards

Inheritance and Genetics (48 cards)

1
Q
A
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2
Q

What is meant by “pure-breeding stock”?

A

Individuals that consistently produce offspring with the same phenotype when self-fertilized or crossed within the same line

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3
Q

What’s the mechanism of inheritance?

A

How traits are passed from parents to offspring

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4
Q

What are the three major historical hypotheses about inheritance?

A
  1. Blending inheritance – parental traits mix into an intermediate form.
  2. Particulate inheritance (haploid) – offspring inherit one unchanged “particle” per trait.
  3. Particulate inheritance (diploid) – offspring inherit two particles (alleles) per trait that segregate during reproduction.
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5
Q

If inheritance were blending, what would F1 offspring look like from dark × light parents?

A

All medium-colored

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6
Q

If inheritance were blending, what would the F2 offspring look like?

A

All medium-colored (variation would disappear)

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7
Q

If inheritance were particulate, haploid, what would we expect in the F1 generation?

A

Offspring would resemble one parent or the other, not intermediates

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8
Q

If inheritance were particulate, diploid, what would we expect in the F1 generation?

A

All offspring would appear the same, but traits of both parents could reappear in F2

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9
Q

Why were F2 results crucial for distinguishing among hypotheses?

A

Only the diploid particulate model predicted re-emergence of the original parental forms in specific ratios

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10
Q

According to Mendel’s model, how is hereditary information carried?

A

By genes, which exist in different versions called alleles

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11
Q

How many copies of each gene does an individual carry?

A

Two — one inherited from each parent

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12
Q

What happens to alleles during gamete formation?

A

They segregate, so each gamete carries one allele

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13
Q

What do the genetic terms dominant and recessive mean?

A

They describe the phenotype of heterozygotes: the dominant allele determines the phenotype when paired with a recessive allele

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14
Q

Why is it misleading to think of dominance as a property of alleles themselves?

A

Because dominance/recessiveness only describe allele interaction, not inherent qualities of the alleles

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15
Q

What gametes are produced by parents with genotype PP?

A

Only gametes carrying P

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16
Q

What gametes are produced by parents with genotype Pp?

A

Gametes with either P or p

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17
Q

What gametes are produced by XRXr parents?

A

Gametes with XR or Xr

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18
Q

What gametes are produced by A1A2 parents?

A

Gametes with A1 or A2

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19
Q

What gametes are produced by S+S parents?

A

Gametes with S+ or S

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20
Q

What is a gamete?

A

A sex cell (sperm or egg) that carries only one copy of each gene. Gametes are haploid.

21
Q

What is an allele?

A

A version of a gene. Different alleles produce variation in traits (e.g., purple vs. white flowers).

22
Q

What does haploid (n) mean?

A

A cell with one set of chromosomes (one copy of each gene).

Example: gametes (sperm/egg).

23
Q

What does diploid (2n) mean?

A

A cell with two sets of chromosomes (two copies of each gene, one from each parent).

Example: most body cells in humans and plants.

24
Q

What is a zygote?

A

The first cell formed when two gametes fuse at fertilization; it is diploid, carrying one set of chromosomes from each parent.

25
How are gametes, haploid, diploid, alleles, and zygote connected?
Diploid parents have two alleles for each gene. They make haploid gametes, which carry one allele per gene. Two gametes fuse to form a diploid zygote, restoring two alleles per gene (one from each parent).
26
Why do some chromosomes look like an “I” and others like an “X”?
It depends on whether the chromosome has been replicated.
27
What does an “I-shaped” chromosome represent?
A single, unreplicated chromosome (one DNA molecule with one chromatid). This is what chromosomes look like most of the time in a cell.
28
What does an “X-shaped” chromosome represent?
A replicated chromosome (two identical sister chromatids joined at a centromere). This form appears after DNA replication, during cell division.
29
Are “X-shaped” chromosomes always two chromosomes?
No — even though it looks like two “sticks,” it’s still considered one chromosome, because the sister chromatids are joined at the centromere.
30
What question do dihybrid crosses test?
Whether alleles of different genes are transmitted together (dependent assortment) or independently.
31
What does the principle of independent assortment state?
Alleles of different genes segregate independently during gamete formation.
32
Why is the principle of independent assortment considered “misleading”?
Because it’s not always true — genes that are physically close on the same chromosome may be inherited together (linkage).
33
What is the difference between a chromosome and a chromatid?
A chromosome is the whole structure (DNA + proteins). After replication, each copy is a chromatid; two sister chromatids = one replicated chromosome.
34
How do you represent chromosome number using n?
n = haploid number (number of unique chromosome types). ## Footnote 2n = diploid number (total chromosomes in diploid cells).
35
What is the outcome of mitosis?
Two genetically identical diploid cells with the same chromosome number as the parent.
36
What is the outcome of meiosis?
Four haploid gametes, each with half the chromosome number of the parent; they are genetically different due to independent assortment and crossing over.
37
What process creates new allele combinations during meiosis?
Crossing over between homologous chromosomes.
38
How are chromosomes distinguished from each other?
By size and shape
39
If a cell has 2n = 6, what is n?
n = 3 (haploid number), 2 = ploidy
40
What is the starting condition for both mitosis and meiosis?
Diploid cells with replicated chromosomes
41
What is the Chromosome Theory of Inheritance?
Genes are located on chromosomes, and meiosis explains Mendel’s principles
42
How does meiosis explain Mendel’s principle of segregation?
Segregation occurs because homologous chromosomes separate during meiosis I
43
How does meiosis explain Mendel’s principle of independent assortment?
Independent assortment occurs because maternal and paternal homologs line up independently during meiosis I
44
How do sex chromosomes determine sex in humans vs birds?
Humans: XX = female, XY = male Birds: ZW = female, ZZ = male
45
How are sex-linked traits written in genotypes?
As alleles on the X (or Z) chromosome, e.g., XB or Xb
46
Which genes violate the principle of independent assortment?
Genes found on the same chromosome, if no crossing over occurs between them (linked genes)
47
What allows linked genes to sometimes assort independently?
Crossing over between homologous chromosomes
48
What is recombination?
The exchange of DNA between homologous chromosomes during meiosis, producing new allele combinations