LECTURE 1

Question 1

classical mutation

Answer 1

heritable change in gene that resulted in a change in phenotype

Question 2

modern molecular term for mutation

Answer 2

heritable change to the sequence of a DNA molecule

Question 3

what did beadle and tatum show?

Answer 3

one-gene-one-enzyme hypothesis

Question 4

beadle and tatum model

Answer 4

neurospora
- isolated auxotrophs that could only grow with arginine

Question 5

what did beadle and tatum identify?

Answer 5

3 genes on 3 different chromosomes
arg -1
arg -2
arg-3

Question 6

what did each arg enzyme do

Answer 6

arg1–>omithrine–>arg2—>citruline—>arg3—>arginine

Question 7

what did beadle and tatum conclude

Answer 7

each gene give rise to a different enzyme that catalyses a different chemical reaction

“each gene in an organism corresponds to a single enzyme, and vice versa”