Lecture 10

Question 1

2 functional units of the liver

Answer 1

Lobular arrangement

Liver acinus

Question 2

Liver acinus arrangement (ZONES)

Answer 2

Zone 1 - glycogen and plasma protein production
2
3- detoxification

Question 3

Functions of Bile

Answer 3

1. Emulsification of fats
2. Neutralises stomach acid
3. Excretory channel for bilirubin

Question 4

2 areas in the liver lobule responsible for blood supply

Answer 4

• portal triad
  Composed of, hepatic artery, bile duct, hepatic portal v
• central vein
  Takes blood away from the lobule to the IVC

Question 5

Blood pressure in liver

Answer 5

Quite low, but with low resistance, it is possible for this.

- cirrhosis leads to ↑ vascular resistance= low blood supply

Question 6

Functions of the liver

Answer 6

Produce bile
Metabolism of carbs, fats and proteins
Detoxification of toxins

Question 7

Function of kupffer cells

Answer 7

Destroy pathogens and old RBC

Question 8

Glucose buffer in the liver

Answer 8

• glycogen storage
• convert galactose and fructose to glucose
• amino acids —> glucose (gluconeogenesis)
• fats —> glucose

Question 9

Fat stores, energy in liver

Answer 9

Fatty acids = ketone bodies and ATP (energy)- beta oxidation
Glycerol = glucose