Lecture 15

Question 1

resting membrane potential

Answer 1

-60 to -70mV

Question 2

2 cause of resting membrane potential

Answer 2

concentration gradient
selective permeability

Question 2

concentration gradient

Answer 2

Na lot out, K lot in, Cl lot out, A lot in

Question 3

selective permeability

Answer 3

Na, Cl, A low permeability
K high permeability

Question 3

Nernst equation

Answer 3

(2.3RT)/(zF)*log([out]/[in])

Question 3

why membrane potential close to equilibrium potential for K

Answer 3

b/c dominant permeability is to K

Question 4

equilibrium potential for K, Na, Cl

Answer 4

equilibrium potential for K
-90mV
equilibrium potential for Na
+70mV
equilibrium potential for Cl
-80mV

Question 5

Na K pump

Answer 5

ATP is bound
ATP phosphorylated, ADP release
carrier change conformation, lose affinity of Na, high affinity to K
bind 2K
change conformation, 2K release inside