Lecture 2

Question 1

What group do all common nucleotide coenzymes and ATP have in common?

Answer 1

Adenine-ribose-P

Question 2

What are ways that reactions with positive delta G’° can proceed?

Answer 2

1. Couple with ATP hydrolysis to make additive negative delta G’°
2. Change concentrations
3. Change temperature

Question 3

Why do the phosphoanhydride bonds of ATP have high energy?

Answer 3

There is high charge repulsion in ATP, but the ADP + Pi products are resonance stabilized. This results in a very large negative deltaG gap between the reactants and products.