Lecture 3 - Dendritic Cells

Question 1

At what stage/s are DCs involved in an immune response?

Answer 1

•  Key in both innate and adaptive immune responses
•   Immature and mature forms
•   Antigen presentation»_space; T cells

Question 2

MHC class I presents antigens to CD4+ or CD8+ T cells?	
 

Answer 2

Class MHC I proteins:

• Found on virtually on all body cells
• Present antigens to CD8+ T cells

Class MHC II proteins:

• Found only on certain cell types
• Professional APC
• Present antigens to CD4+ T cells

Question 3

Immature DC precursors come from where?

Answer 3

• Come from bone marrow

Question 4

Mature DCs are found where?

Answer 4

• In lymph nodes

Question 5

Name the cytokines which can induce T cell tolerance

Answer 5

Naïve T cell to regulator T cell
- TGF-B

Naïve T cell to T helper 1 cell

• IL-12
• IL-18

Naïve T cell to T helper 2 cell

• IL-4
• IL-10

Naïve T cell to T helper 17 cell

• IL-1
• IL-6
• IL-21
• IL-23
• TGF-B

Question 6

Name the cytokines which can induce T cell activation

Answer 6

• CD 80
• CD 86
• IL-12
• TNF
• IL-10

Question 7

Name some of the potential co-stimulatory molecules

Answer 7

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Question 8

What is the difference between PAMPs and DAMPs?

Answer 8

.DAMPs: initiate and perpetuate a noninfectious inflammatory response

PAMPs: initiate and perpetuate the infectious pathogen-induced inflammatory response

Question 9

What are some of the mechanisms by which DC vaccines are enhanced?

Answer 9

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Question 10

Why are DCs the best APC at T cell priming?

Answer 10

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