Lecture 4

Question 1

What are the types of polymorphisms?

Answer 1

SNP (Single Nucleotide Polymorphism), RFLP (Restriction Fragment Length Polymorphism), VNTR (Variable Number Tandem Repeat), SSR (Simple Sequence Repeat), & CNV’s (Copy Number Variant)

Question 2

Why do polymorphisms not have a profound, if any effect at all on phenotype or expression of disease?

Answer 2

Polymorphisms normally occur around genes, but not on them (Introns).

Question 3

Difference between a polymorphism and mutation?

Answer 3

Look this up

Question 4

What are the two types of VNTRs?

Answer 4

Simple Sequence Repeats (SSR, microsatellites) & Short Tandem Repeats (STR, minisatellites)