lecture 5

Question 1

Alpha-BSM applications?

Answer 1

Dental Applications & Orthopedic

Question 2

controls drug release in ocusert?

Answer 2

EVA: Ethylene-vinyl acetate

Question 3

drugs used in the gastro-retentive system?

Answer 3

• Drugs with limited acid solubility: Phenytoin
• Drugs that suffer instability in gastric environment erythromycin
• Drugs intended for selective release in colon: 5-Amino-Salycilic Acid

Question 4

factors that affect gastric retention?

Answer 4

• density of dosage form
• shape & size of dosage form
• food intake & its nature
• Gender & Age

Question 5

Mechanism of MucoAdhesion?

Answer 5

• Wetting theory
• Diffusion theory
• Chemical Bond formation: Primary (Covalent)& Secondary (Van der waals & hydrogen bond)

Question 6

Mucoadhesion characteristics?

Answer 6

• flexibility
• hydrophilicity
• hydrogen bonding
• high mwt
• low surface tension