Lecture 8 material

Question 1

For the General Model, what are the Five sites of interaction? describe each

Answer 1

1. ) Uptake
2. ) Action: acts upon the organism
   - Target structure/macromolecule -Manifestation of toxicity
3. ) Metabolism: acts upon the chemical -Usually detox
4. ) Storage: inactive
   - Unmetabolized or metabolic product
5. ) Excretion: acts on product

Question 2

General Model: Movements depend on_____

Answer 2

Kow

Question 3

what is toxicokinetics?

Answer 3

• uptake, distribution, metabolism

- How much goes where

Question 4

what is toxicodynamics?

Answer 4

• interaction at action site

- Nature and degree of reaction

Question 5

describe the processes of uptake

Answer 5

-Typically through passive diffusion 
• Bulk transport with other lipids 
• Some degree of solubility 
• ↓Kow > 1 > ↑Kow 
(other factors matter too)
-Molecule Equilibrium
• Some forms are preferentially absorbed
(page 5)

Question 6

describe the processes of distribution in vertebrates (4)

Answer 6

• Digestive system –>blood–>liver
• Respiratory system–> blood –>other
• Adsorption from blood depends on Kow
• Crossing the blood-brain barrier

Question 7

describe the processes of distribution in invertebrates (2)

Answer 7

• Blood = hemolymph

* Respiration = spriacles

Question 8

describe the processes of distribution in plants (2)

Answer 8

• Xylem - apoplastic

* Phloem - symplastic

Question 9

what is bioaccumulation?

Answer 9

textbook

Question 10

slide 7

Answer 10

?

Question 11

slide 8

Answer 11

?

Question 12

slide 9

Answer 12

?

Question 13

Enzymatic detoxification activity is a function of …. (3)

Answer 13

size, habitat, and trophic position

Question 14

slides 11-13

Answer 14

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