Lecture 9

Question 1

A ____potent stem cell is derived from a self-renewing stem cell in the bone marrow. It gives rise to ______ progenitor cells (Band T-cells) and ______ progenitor cells (the other leukocytes.)

Answer 1

PLURIpotent

LYMPHOID

MYELOID

Question 2

Two most important qualities of the T-cell repertoire are:

1. Self-_____ restricted
2. Self-_____ (does not recognize self-peptide.)

Answer 2

1. self-MHC restricted

2. self-TOLERANT

Question 3

The thymus is comprised of two components:

1. _____, where cortical ______ cells reside
2. _____, where _____-derived DCs and macrophages reside.

Answer 3

1. CORTEX, where cortical EPITHELIAL cells reside

2. MEDULLA, where BONE MARROW-derived DCs and macrophages reside.

Question 4

Once stem cells enter the thymus, they’re known as _____.

Answer 4

THYMOCYTES

Question 5

T-cell maturation begins with rearrangement of the ____ chain of the TCR followed by the ___ chain. Then, it will express both CD4 and CD8.

Answer 5

BETA

ALPHA