What is blood fractionation?
Separation of blood into basic components based on centrifugation and coagulation
What is hematocrit?
Total volume of whole blood that is RBCs; typically 37% to 52%
What is the buffy coat?
Narrow cream-colored zone containing WBCs and platelets; 1% or less of total volume
What constitutes blood plasma?
Complex mixture of water, proteins, nutrients, electrolytes, nitrogenous wastes, hormones, and gases
What are the three major categories of plasma proteins?
What is the function of albumins?
Transport of solutes, buffer plasma pH, contribute to viscosity and osmotic pressure
What are the subclasses of globulins?
What is hematopoiesis?
Production of blood, especially its formed elements
What is the role of hematopoietic tissues?
Produce blood cells
What are the two types of hematopoiesis?
What do erythrocytes do?
Carry oxygen from lungs to tissues and carry carbon dioxide from tissues to lungs
What happens to erythrocytes as they age?
RBC proteins deteriorate, membranes become fragile, leading to hemolysis
What is anemia?
Condition characterized by a deficiency of red blood cells or hemoglobin
What is the ABO blood group?
Blood types A, B, AB and O determined by the presence or absence of antigens A and B on RBCs
What is hemolytic disease of the newborn (HDN)?
Condition that may occur when a Rh− mother has a Rh+ baby, leading to agglutination of fetal RBCs
What are leukocytes?
White blood cells that protect against infection and other diseases
What are granulocytes?
A group of WBCs that contain specific granules and include neutrophils, eosinophils, and basophils
What is the function of neutrophils?
Aggressively antibacterial; increase in bacterial infections and phagocytize bacteria
What are the two reaction pathways to coagulation?
What is hemostasis?
The process of blood clotting and the prevention of excessive bleeding
What are procoagulants?
Clotting factors present in plasma, usually produced by the liver
What is the function of the pulmonary circuit?
Supplies oxygen-poor blood to the lungs for oxygenation
What is the structure of the pericardium?
A double-walled sac enclosing the heart, consisting of fibrous and serous layers
What is the myocardium?
Layer of cardiac muscle whose thickness is proportional to workload