Leprosy

Question 1

Dapsone MOA

Answer 1

Folic acid synthesis inhibition
Static

Question 2

Dapsone kinetic

Answer 2

Hepatic metabolization
Urine clearance

Question 3

Dapsone side effects

Answer 3

1. GI
2. Fever
3. Rash
4. G6PD hemolytic anemia

Question 4

Clofazimine

Answer 4

• Anti-inflammatory
• Anti Leprosy MOA not known
• GI edema
• GI obstruction

Question 5

Mycobacterium Avium Complex (MAC)

Answer 5

• Clarithro, Azithro
• Rifabutin
• Macrolide + EMB