Leukemia

Question 1

Here is a handy image.

Maturation stages of blood cells.

Answer 1

Question 2

What is Hematopoiesis?

Answer 2

The formation of blood cells

Question 3

What is Leukemia?

Answer 3

Leukemia is the proliferation of malignanat WBC’s present in the circulation.

Question 4

What does the suffix -blast, represent?

Answer 4

It represents immature forms of cells. Ex. Monoblasts are immature Monocytes, Erythroblasts are immature Erythrocytes

Question 5

What does the suffix -cycts represent?

Answer 5

It represents a mature type of cell Ex. Monocytes, Neutrophils

Question 6

In what demographic is Leukemia most prevelant?

Answer 6

Most common type of CA in children and young adults

Question 7

Which two cell lineages is affected by Leukemia?

Answer 7

The Lymphoid and Myeloid lineages

Question 8

How many different classifications of leukemia do we have?

Answer 8

4 Acute and Chronic Lymphocytic Leukemia Acute and Chronic Myelogenous Leukemia

Question 9

Chronic is defined as:

Answer 9

Less aggressive It affects the more mature blood cells

Question 10

Acute is defined as:

Answer 10

More aggressive It affects the immature cells, the blast cells

Question 11

What is the cause of Leukemia?

Answer 11

Idiopathic - We do not know the cause, however, we do know that it is a mutation of gene’s.

Question 12

What are some risk factors to developing Leukemia?

Answer 12

1. genetic predispostion, and increased exposure to radiation (lower dose, frequent exposure like x-rays which target nucleus and genetic DNA) 2. immunodeficiency, t-cell leukemia virus (virus need host DNA to replicate, incorporating and altering host DNA) 3. non-malignant blood cell production also affected (restricted space in bone marrow, less room for production of normal cells, impaired immune response, and decreased oxygen supply)

Question 13

Name the manifestations of Leukemia?

Answer 13

1. anemia (decreased oxygen transport) 2. thrombocytopenia (decreased platelets) 3. leukopenia (decreased leukocytes) 4. bleeding gums, fever, generalized pain 5. fatigue, weakness, bruising 6. recurrent infections

Question 14

What are the 3 treatment stages for Leukemia?

Answer 14

1. induction 2. intensification 3. maintenance

Question 15

How do you treat Leukemia?

Answer 15

Radiation, and Chemotherapy (Using the 3 treatment stages) Transfusions Antimicrobials Colony stimulating (CS) factors, also known as Blood Boosters

Question 16

What is a last option treatment for Leukemia?

Answer 16

Bone Marrow Transplant