Leukemia

Question 1

EBV causes

Answer 1

Burrkett’s leukemia/lymphoma

Question 2

HTLV1 causes

Answer 2

Adult T cell leukemia

Question 3

Pulmonary leukostasis is more common in

Answer 3

AML

Question 4

Coagulopathy is common in which AML?

Answer 4

AML M5 + AML M3

Question 5

RES infiltration is common in

Answer 5

ALL

Question 6

Gum hypertrophy is common in

Answer 6

AML M5

Question 7

Sweet’s syndrome and chloroma

Answer 7

AML

Question 8

• 15 to 20 micro m.
• fine chromatin.
• predominant nucleoli 1-4.
• moderate basophilic cytoplasm.
• Auer rods may present.

Answer 8

Myeloblast

Question 9

• 10 to 15 micro m.
• condensed chromatin.
• scanty cytoplasm.
• inconspicuous nucleoli 1-2.
• auer rods are absent.

Answer 9

Lymphoblast

Question 10

Neutrophil primary granules are stained in?

Answer 10

Myeloperoxidase (MPO) (myeloblasts strong +ve, monoblasts faint +ve)

Question 11

Phospholipids are stained in?

Answer 11

Sudan black B (SBB)

Question 12

Cellular enzymes are stained in ?

Answer 12

Specific esterase (myeloblasts strong +ve)

Question 13

M2 , M3 ,M4eo

Answer 13

Favorable prognosis

Question 14

M0, M1, M5, M6, M7

Answer 14

Unfavorable prognosis

Question 15

t(8,21), t(15,17), inv(16), normal CG

Answer 15

Favorable prognosis

Question 16

t(9,22), -5, -7, +8. Complex CG

Answer 16

Unfavorable prognosis

Question 17

Adverse prognostic factors in ALL: ( high risk)

Answer 17

t(9,22).
t(4,11).
trisomy 8.
Hypodiploidy

Question 18

Postremission therapy aimed at destroying clinically occult disease.

Answer 18

Remission consolidation (intensification) therapy

Question 19

Low dose of chemotherapy aimed at preventing the reemergence of leukemia.

Answer 19

Maintenance (continuation) therapy

Question 20

Initial chemotherapy treatment aimed at achieving a complete remission.

Answer 20

Remission induction therapy

Question 21

Complete remission of leukemia

Answer 21

■ Disappearance of leukemia after treatment with full regeneration of normal hematopoiesis.

■ <5% blasts in a normocellular bone marrow.

■ Return of peripheral blood count to normal:

■ Neutrophils count > 1500/µL. ■ Platelets count >100,000/µL. ■ hemoglobin level >10 gm/dL.

■ Disappearance of sings and symptoms.

Question 22

Persistent leukemia, not detectable by light microscopy.

Answer 22

Minimal residual disease

Question 23

Leukemia that does not enter CR.

Answer 23

Refractory Leukemia

Question 24

WBC> 100 000

Answer 24

AML

Question 25

WBC> 200 000

Answer 25

ALL

Question 26

Cytoreduction Tx for AML

Answer 26

Hydroxyurea

Question 27

Cytoreduction Tx for ALL

Answer 27

Steroids

Question 28

Allopurinol + Rasburicase

Answer 28

Used to treat Tumor Lysis Syndrome

Question 29

FFP + cryoprecipitate are used to treat

Answer 29

DIC coagulopathy In Leukemic patients

Question 30

Acute leukemia associated with CNS disease at presentation?

Answer 30

ALL

Question 31

Aim is to reconstitute normal hematopoiesis and to prevent GVL effect.

Answer 31

Allogeneic SCT

Question 32

high-dose ara-C is used in?

Answer 32

Remission consolidation therapy (post remission)

Question 33

ATRA (all trans retinoic acid) is used to treat?

Answer 33

AML M3

Question 34

Used to treat AML M3, and can result in differentiation syndrome?

Answer 34

ATRA (all trans retinoic acid)

Question 35

Which of the following is NOT done to manage differentiation syndrome resulted from ATRA Tx? - Hold ATRA. - Stop ATRA. - Give dexamethasone. - Give diuretics.

Answer 35

Stop ATRA

Question 36

Induces apoptosis in the leukemic cells

Answer 36

``` Arsenic trioxide (ATO) *induces cardiotoxicity + neurotoxicity ```

Question 37

Hyper CVAD drugs used to treat

Answer 37

ALL

Question 38

For relapsed or patients with high risk to develop leukemia

Answer 38

Allogeneic SCT

Question 39

Leukemia mainly seen in children

Answer 39

ALL

Question 40

Leukemia mainly seen in elderly

Answer 40

CLL

Question 41

The most common malignancy in childhood?

Answer 41

ALL

Question 42

Which of the following is specific manifestation of AML? - Gumhypertrophy. - violaceous skin deposits. - Testicular enlargement. - mediastinal mass (SVCO).

Answer 42

A and B

Question 43

- Testicular enlargement. | - mediastinal mass (SVCO). Both are specific for?

Answer 43

ALL

Question 44

DIC is specific for which leukemia?

Answer 44

AML