Lipids

Question 1

Primary Hyperlipidemias

Answer 1

➡️Type 1 : hyperchylomicronemia
- AR
- def LPL, CII
- ⬆️ CM eTG
- pancreatite

➡️ type 2: Hypercholesterolemia
-AD
- def LDL -R , apo B100
- acumulo de LDL
- grave , infarto < 20 anos
-Tendon xanthomas
Corneal archis

➡️ type 3 dysbetalipoproteunemia
- AR
- def Apo E
- Acumulo de CHL , TG, VLDL, CM-r
- aterosclerose e xantomas palmar

➡️type 4 hypertrigliceridemiaa
AD
overlroduction of VLDL
⬆️ TG VLDL
Pancreatite
Related o DM II

Question 2

Secondary hyperlipidemia

Answer 2

Alcoholism
Bet a blocker
Pregnancy
HCTZ - lipids glicemia, calico
Nephrotoc syndrome

Question 3

LdL goal

Answer 3

DM or coronary art disease < 100
2 or more risk factors < 130
0 or 1 risk factor. < 160

Patient with CV risk of 5% / year regardless LDL level ( 🔺always statins independent of LDL VALUE )

Question 4

Beta oxidation
Odd chain FA
Quais Sao as etapas?

Answer 4

• cadeia impar de carbonos no fatty acid

-Propionyl Coa ➡️ Methylmalonyl CoA➡️ ( B12) Succinyl Coa ➡️ TCA Cycle

Sources of propionyl CoA:
VOMIT
V - valine
O- Odd chain
M- Methionine
I- Isoleucine
T- Threonine

Question 5

CARNITINE DEFICIENCY

Answer 5

Causes: diet, burn, mutation
- FA can’t enter in mitochondria
- FA accumulate in cytoplasm
-muscle weakness + cardiomegaly
🔺 hypoglycemia and hypoketotic
Can’t produce acetil CoA