Function 1: produces bile
Bile breaks up fatty acids in small intestines
Stored in gallbladder until its released
Function 2: Processes blood from stomach and intestines
Stores some vitamins
Processes fats and proteins
Inactivated drugs and toxins
Stores glucose as glycogen
Lobes of the liver
4 lobes
Left, right, quadrate, & caudate
Hepatic portal vein
Gathers blood from digestive organs and transports it into the liver
Low in oxygen
Hepatic proper artery
Provides oxygen rich blood to the liver
Inferior vena cava
Removes blood from the liver after its been processed
Liver cell organization
Organized into 50k to 100k lobules
Portal triads
Blood vessels and ducts are organized into the triads at each lobule corners
- Bile duct: transports bile out of lobule
- Portal Venule: Transports nutrient rich blood into the lobule
- Portal Arteriole: Transports oxygen rich blood into the lobule
Sinusoids
Channels through which the arterial and venous blood mix
Central Vein
Drains blood from sinusoids and out of the liver
Hepatocytes
Primary cell of the liver, many functions
Arranged into plates in the lobules
- Produce bile that’s removed via the bile canaliculi
- Metabolize and store various substances from the blood
- Great ability to regenerate
Flow of blood in lobules
Bile flow
Hepatocytes to bile canaliculus to the bile duct
Hepatic macrophages
Kupffer cells
Move through the sinusoids
- Destroy bacteria and old blood cells
Common hepatic duct
Bile duct draining away from liver
Portal system
Blood flows through 2 capillary beds before returning to the heart
- Stomach and intestine
-Liver
Both form the hepatic portal system
What is in bile
Cholesterol, bile acids, salts, and bilirubin
Gallstones
Usually formed of cholesterol that precipitates out of bile while it is stored in the gallbladder