What does elevated AST and ALT represent?
Hepatocellular damage
What does elevated Alkaline phosphatase represent?
Bile duct problems (cholestasis)
What does elevated Gamma glutamyl transferase represent?
Bile duct epithelium/cannalicular membrane injury
What cellular marker resides in mitochondria?
AST
What does ETOH toxicity preferentially elevate?
AST
What does a positive ANA test represent?
Autoimmune hepatitis
What does a positive anti-smooth muscle antibody test represent?
Autoimmune hepatitis
What does decreased ceruloplasmin represent?
Wilson’s disease
What does a positive AMA-M2 represent?
Primary biliary cirrhosis
Why do you do a liver biopsy?
Determine cause of liver disease
Determine extent of damage to the liver
What does “Stage” mean for chronic hepatitis? What about “Grade”?
Stage: Degree of fibrosis
Grade: Severity of necro-inflammatory activity
