What is a benefit of fresh frozen biopsy samples over formalin fixed samples?
a. They allow for functional staining of samples
b. They can be used for electron microscopy
c. They provide better look at tissue architecture
They allow for functional staining of samples
Cervical ventroflexion is a nonspecific sign of weakness in cats. What is the incidence of this among cats with immune mediated polyneuropathy?
a. 87%
b. 34%
c. 11%
d. 50%
c. 11%
What change on gait, listed below, is a sign of early limb weakness
a. Overflexion of distal joints
b. Scuffing of dorsal digits
c. Increased stride length
a. Overflexion of distal joints
Which of these clinical signs distinguishes myopathies from neuropathies?
a. Muscle Atrophy
b. Muscle Hypertrophy
c. Generalized Weakness
d. Generalized Ataxia
b. Muscle Hypertrophy
What is the serum halflife of creatine kinase in dogs, that makes it a good biomarker of myopathies?
a. 2.5 hours
b. 5.4 hours
c. 11.5 hours
a. 2.5 hours
What portions of the neurologic examination help you best differentiate between a patient with spinal cord disease and a patient with neuromuscular disease?
a. Paw placing and the cranial nerve exam.
b. Paw placing and limb reflex testing.
c. Limb reflex testing and the cranial nerve exam.
b. Paw placing and limb reflex testing
F waves are best utilized to diagnose which of the following canine neuromuscular diseases?
a. Tetanus
b. Polyradiculoneuritis
c. Distal denervating neuropathy
b. Polyradiculoneuritis
What is true about Cushing’s myotonia?
a. This disease causes type 1 muscle atrophy and distal appendicular muscle hypertrophy.
b. This disease causes a pseudomyotonia on EMG analysis.
c. This disease results in thoracic limb stiffness and pelvic limb flaccidity.
b.
This disease causes a pseudomyotonia on EMG analysis
What are the three categories of neuromuscular or peripheral nervous system disease:
a. Disease of the neuromuscular junction
b. Disease of the peripheral nerve
c. Disease of the peripheral muscle
d. All of the above
d. All of the above
What electrophysiologic exam finding is observed with a demyelinating neuropathy?
a. Increased M wave amplitudes.
b. Decreased motor nerve conduction velocities.
c. Lack of polyphasia on motor nerve conduction velocity testing.
b. Decreased motor nerve conduction velocities.
Which serum marker has the best sensitivity and specificity to support a diagnosis of Neospora myositis in dogs?
a. Alanine aminotransferase
b. Aspartate aminotransferase
c. Creatine kinase
d. Alkaline phosphatase
c.
Creatine kinase
Which protozoal myopathies affect the cat and the dog commonly?
a. Cryptococcus in cats and in dogs
b. Neospora in cats and in dogs
c. Toxoplasma in cats and Neospora in dogs
d. Toxoplasma in dogs and Neospora in cats
c. Toxoplasma in cats and Neospora in dogs
Why is neck ventro-flexion a common sign of neuro-muscular weakness in cats?
a. Cats’ nuchal ligament attaches on C3
b. Cervical muscles in cats are weaker than thoracic and lumbar muscles
c. Cats lack a nuchal ligament
d. Cats’ nuchal ligament attaches on C4
c. Cats lack a nuchal ligament
Which metabolite can be increased in the urine and support a diagnosis of lipid storage myopathy?
a. Carnitine
b. Tetrasaccharide
c. Creatine
d. Tricarboxylic acid
a. Carnitine
Which diseases can lead to a decremental muscle response after repetitive nerve stimulation?
a. Myasthenia gravis, polymyositis
b. Myasthenia gravis, polymyositis, severe polyneuropathies
c. Polymyositis, severe polyneuropathies
d. Myasthenia gravis, severe polyneuropathies
b. Myasthenia gravis, polymyositis, severe polyneuropathies
Angular atrophy of type i and 2 myofibers is the hall mark of?
a. Muscle disuse
b. Masticatory muscle myositis
c. Denervation
d. Muscular dystrophy
c. Denervation
Chronicity of disease is associated with?
a. Fiber type grouping
b. Large group atrophy
c. Pyknotic nuclear clumps
d. All of the above
d. All of the above
Which of the following appear dark stained on ATPase with preincubation at pH 4.3?
a. Type 2B myofibers
b. Type 2M myofibers
c. Type 2A myofibers
b. Type 2M myofibers
Which of the following is a specific mitochondrial stain?
a. Succinic dehydrogenase
b. Alkaline phosphatase
c. Acid phosphatase
d. Nicotinamide adenine dinucleotide-tetrazolium reductase (NAD)
a. Succinic dehydrogenase
Staphylococcus protein A highlights which leukocyte population?
a. Macrophages
b. Plasma cells
c. Eosinophils
d. T lymphocytes
c. Eosinophils
Which histochemical muscle fiber type is restricted to the muscles of mastication?
a. Type 2A
b. Type 1
c. Type 2M
d. Type 2C
c. Type 2M
Regenerating clusters are a histological marker for what?
a. Distal polyneuropathy
b. End-stage axonal degeneration
c. Axonal regeneration
d. Remyelination
c. Axonal regeneration
Necklace fibers are a hallmark of which muscle disease?
a. Central core myopathy
b. X-linked Myotubular myopathy
c. Nemaline rod myopathy
d. Dystrophin deficient muscular dystrophy
b. X-linked Myotubular myopathy
Which one of the following histochemical reactions is mitochondrial specific?
a. Cytochrome C Oxidase
b. Periodic acid-Schiff (PAS)
c. Esterase
d. Reduced Nicotinamide Adenine Dinucleotide tetrazolium reductase (NADH-TR)
a. Cytochrome C Oxidase