Loop Diuretics

Question 1

Mechanism of action

Answer 1

Acts in the thick ascending limb of Henle by Na-K-2Cl pumps

Question 2

Excessive used of loop diuretics will cause:

Answer 2

1. Hypokalemic metabolic alkalosis

2. Ototoxicity

Question 3

Pathologic states that alter response to furosemide

Answer 3

1. Congestive Heart Failure
2. Hepatic Disease and Ascites
3. Nephrotic Syndrome
4. Infancy/ Prematurity

Question 4

Clinical indications of loop diuretics

Answer 4

1. Acute pulmonary edema
2. Hypercalcemia
3. Hyperkalemia