1
Q
Lorazepam Elimination Half Life
A
10-20 hours
2
Q
Lorazepam Lipid solubility
A
Less than diazepam
3
Q
Lorazepam Absorption
A
Reliable GI & IM- dissolved in propylene glycol or polyethelyne glycol
4
Q
Lorazepam Mechanism of Action
A
GABA A receptor, dissociates slower than diazepam
5
Q
Lorazepam Metabolism
A
To inactive metabolites via glucuronide conjugation in liver, not altered by age, liver dysfunction or H2 receptor antagonists (cimetidine)
6
Q
Lorazepam PO Dosing
A
0.5-2.0 mg @ HS, 0.5-2.0 mg in AM of surgery.
7
Q
Lorazepam Dosing for amnesia
A
50 mcg/kg (max 4 mg) amnesia for 6 hours, larder doses produce greater sedation without increased amnesia
Intravenous Anesthetics
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