Lung

Question 1

Rearrangements treated with crizotinib ?

Answer 1

ALK or ROS1

Question 2

Loss of which marker favors malignant mesothelioma over a benign mesothelioma proliferation ?

Answer 2

BAP 1 negative ( nuclear) - correlates with homozygous deletions of p16/CDKN2A by FISH.