Lupus

Question 1

Lupus broad definition

Answer 1

Hyperactive T and B cells caused by humoral and CMI responses
- caused by inability to remove apoptotic bodies allowing B-cells to generate antibodies to react to the apoptotic bodies. Specifically the nuclear remnants of the apoptotic bodies

include type 2-4 hypersensitivity
- primarily type 3 hypersensitivity though

Question 2

ANA

Answer 2

Antinuclear antibodies, always present in patients with lupus, however ANA alone does not induce lupus

• most common ANAs found in lupus is anti-DsDNA and anti- Sm

Question 3

ANA complexes

Answer 3

Form with antigens and self nuclear antigens

• deposit in random areas triggering compliment and a self fulfilling cycle where antibodies keep being created and not being removed

Question 4

Where do the immune ANA complexes precipitate

Answer 4

Vascular basement membranes and activate compliment

• can lead to vascular, kidney and arthritis

Question 5

Malar/ butterfly rush

Answer 5

Most common sign with lupus

• runs along the cheeks, bridge of nose and eyelids
• more prevalent in the sun

most frequently in women in child bearing years
- doesn’t usually occur in babies, however babies that have a mother with lupus can develop heart blocks

Question 6

Other clinical signs of lupus

Answer 6

Predominant signs in only one system, however the system affected various form patient to patient

• potential systems
• lungs