Lymphocyte Abnormalities

Question 1

Associated with degenerated nucleus or RUPTURED CELL in form or basket/smudge.

Answer 1

Basket/smudge cell

Question 2

THUMBPRINT APPEARANCE

Answer 2

Basket/ smudge cell

Question 3

[1] Clinical significance of BASKET/SMUDGE CELL

Answer 3

Chronic Lymphocytic Leukemia

Question 4

Hair like cytoplasmic projections surrounding the nucleus (FRIED - EGG APPEARANCE)

Answer 4

Hairy cell

Question 5

TRAP (Tartrate-resistant acid phosphatase) stain positive.

Answer 5

Hairy cell

Question 6

Clinical significance of HAIRY CELL.

Answer 6

Hairy cell leukemia

Question 7

Lymphocyte with a convoluted nucleus/BRAIN LIKE NUCLEUS.

Answer 7

Sezary cell

Question 8

Presence indicates LEUKEMIC PHASE of mycosis fungoides (Sezary syndrome)

Answer 8

Sezary cell

Question 9

Clinical significance of SEZARY CELL.

Answer 9

Sezary syndrome

Question 10

Abnormal lymphocyte with an “owl’s eye appearance”.

Answer 10

Reed - Sternberg/ RS cells

Question 11

Pathognomonic sign for Hodgkin’s lymphoma

Answer 11

Reed - Sternberg/ RS cells

Question 12

Clinical significance of REED - STERNBERG/RS CELLS.

Answer 12

Hodgkin’s lymphoma

Question 13

:Lymphocyte with a CLOVER LEAF like nucleus.

Answer 13

Rieder cell

Question 14

Clinical significance of RIEDER CELL.

Answer 14

Chronic Lymphocytic Leukemia

Question 15

Turk’s irration plasma cytoid; lymphocyte with a LARGE BLOCK OF CHROMATIN.

[type][reactive lymphocyte]

Answer 15

Type I

Question 16

Also known as IM cells; ROUND MASS OF CHROMATIN (Ballerina skirt appearance)

[type][reactive lymphocyte]

Answer 16

Type II

Question 17

Vacuolated (swiss cheese appearance).

[type][reactive lymphocyte]

Answer 17

Type III

Question 18

Abnormal plasma cell with RED TO PONK CYTOPLASM.

Answer 18

Flame cell

Question 19

Associated with increased Immunoglobulins (usually IgA).

Answer 19

Flame cell

Question 20

Inclusion: RUSSEL BODIES (individual bodies of Immunoglobulin).

Answer 20

Flame cell

Question 21

[2] Clinical significance of FLAME CELL.

Answer 21

1. Multiple myeloma
2. Waldenstrom’s macroglobulinemia

Question 22

Abnormal plasma cell with SMALL COLORLESS VACUOLES.

Answer 22

Grape cell

Question 23

AKA Berry, Mott, Morula Cell

Answer 23

Grape cell

Question 24

Inclusions: DUTCHER’S BODIES (intranuclear protein inclusions.

Answer 24

Grape cell

Question 25

Large protein globules giving appearance of grapes: “Honeycomb appearance”.

Answer 25

Grape cell

Question 26

[2] Clinical significance of GRAPE CELL.

Answer 26

1. Multiple myeloma 2. Reactive states